The majority of side effects from topical steroids occur within the nose at the site of local application. These side effects commonly include nasal irritation and nose bleeds . Should these symptoms occur, a person should stop using the nasal steroid for a few days, and then re-start the medication using the appropriate technique . If bleeding and irritation continue to occur, the nasal steroid should not be used any longer. A person who continues to use a nasal steroid despite these local side effects is at risk for septal perforation .
Study 2 evaluated the proportion of pediatric patients 12 to 17 years of age who had no headache pain at 2 hours following treatment. Headache response (defined as a reduction in migraine-related headache pain severity from moderate or severe pain to mild or no pain) and the absence of nausea, photophobia, and phonophobia at 2 hours post treatment were also assessed. As shown in Table 4, the percentage of pediatric patients 12 to 17 years of age with no headache pain at 2 hours following treatment was significantly higher for Zomig Nasal Spray 5 mg than placebo.