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Lodine is available in capsules at strengths of 200 and 300 mg, and as tablets at strengths of 400 and 500 mg. Usual dosage is 200-400 mg every 6 to 8 hours, not to exceed 1000 mg. Patients with asthma that are aspirin-sensitive should avoid use of this Lodine. Lodine may reduce the effectiveness of ACE inhibitors and increase lithium (Eskalith, Lithobid) levels; use with aspirin or similar agents is not recommended. Caution is advised as Lodine may react with a number of other drugs so the prescribing physician will need a list of current medications. Lodine may interact with ACE inhibitors, aspirin or other NSAIDs , cyclosporine, digoxin, methotrexate, diuretics (water pills), lithium, phenylbutazone, antidepressants , steroids, and blood thinners. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Lodine; taking Lodine during the last 3 months of pregnancy may harm the fetus. Do not take Lodine during pregnancy unless your doctor has told you to. It is unknown if Lodine passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding . Safety and effectiveness in pediatric patients below the age of 18 years have not been established for Lodine.