Corticosteroid cream safe during pregnancy

As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. [28]


Thinning Skin and Hydrocortisone Cream? What are the risks associated with cortisone creams? The primary risk, and what most seem to be concerned about, is thinning of the skin. While that is indeed a risk of using cortisone creams, it is important to stress that this is uncommon, and a risk that develops primarily from long-term, chronic (and excessive) use of cortisone creams. Despite this fact, many people fear thinning of skin is a risk even with responsible use of such treatments, or that it will happen immediately, and that is not the case. [2,3,4]

Corticosteroid cream safe during pregnancy

corticosteroid cream safe during pregnancy

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