Guinea pigs were pretreated for three days with two daily doses of sodium salicylate 400 mg/kg (S), phenylbutazone 24 mg/kg (P) or indomethacin 8 mg/kg (I). None of the drugs produced any effects on the concentrations of cortisol in the plasma, plasma ultrafiltrate or the skin which were significantly different from the control values. The values found after S were, however, higher than after P. The biological half life (t 1/2 ) of exogenous 4- 14 C-cortisol and the apparent volume of distribution (V d ) was unchanged by S. P tended to increase V d while I tended to produce a reduction. The results do not support the theory of a displacement of cortisol from plasma protein as a basis for the antirheumatic effect of the drugs.
Q. Had FMS for almost twenty years now, tried almost everything. Is Lyrica in the "steroid" family? Any one in this community could help me? I have given my few questions to find out an answer. I Had FMS for almost twenty years now, tried almost everything. I'm considering Lyrica but I'd like more info. Is Lyrica in the "steroid" family? If you go on Lyrica for a while & see no improvement with pain, is going off of it a big deal like with other med's, or can you simply just stop taking it? I take Ambien, will that have any interactions? I'm seeing my Doc about this at the end of the month, but I was hoping to get some personal experiences about it. Thanks for any thoughts! Thanks for your answers, keep them coming! A. according to this-
there is a moderate interaction. that means you can take them both but be checked regularly for depression of breath.
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