Do inhaled steroids suppress immune system

When used in high doses, a small amount of the medication is absorbed into the bloodstream and some side effects beyond the mouth and throat may develop. The most likely to be encountered are easy bruisability of the skin and suppression of the adrenal glands. The significance of adrenal gland suppression is discussed in further detail in the pamphlet entitled Asthma and Steroids in Tablet Form , prepared by the Partners Asthma Center. The risk from the long-term use of inhaled steroids in terms of hastening thinning of the bones (osteoporosis) is currently being studied. However, it is widely agreed that any risk that may be discovered will be far less than that resulting from use of steroids in tablet form in doses needed to achieve the same control of asthma.

The aim of this article is to bring less well recognised adverse effects of inhaled corticosteroids to the attention of prescribers. Whilst inhaled steroids have a more favourable side effect profile than systemic steroids, they are not free from adverse effects. The dose of inhaled steroids used should be carefully monitored, and kept at the lowest dose necessary to maintain adequate control of the patient’s disease process. Be particularly aware of the cumulative effect of co-prescribing various dose forms of corticosteroids (inhaled, intranasal, oral and topical preparations).

There is, however, some evidence that higher doses of inhaled corticosteroids can result in adverse BMD changes. In a high-quality RCT of 412 participants, aged 40 to 69 years, with mild to moderate COPD, use of higher-dose triamcinolone (1200 mcg/day) was associated with decreased lumbar and femoral neck BMD over 3 to 4 years. 4 The differences in BMD between the inhaled corticosteroids and placebo groups at the femoral neck and lumbar spine were % ( P <.001) and % ( P =.007), respectively. However, the risk of fracture or height loss did not increase at follow-up.

Great question! Unfortunately, there are side effects to taking steroids – inhaled or oral. However, the risk of suppressing the immune system with inhaled corticosteroids is far less than with the use of systemic steroids.
For a person with asthma, inhaled steroids are an important part of treatment. They reduce the airway inflammation that is the hallmark of asthma. So, when prescribing inhaled steroids most doctors weigh carefully the benefits vs. the risks. Most likely you’re on the lowest possible dose for the severity of your asthma – enough to treat the inflammation and avoid exacerbations. One of the benefits of inhaled steroids is that they are being delivered directly to the area needed, which is one of the reasons a much lower dosing can be used with far less side effects. In fact, it takes about a year of inhaled steroids to equal a 5 day course of oral steroids prescribed during an exacerbation .

Do inhaled steroids suppress immune system

do inhaled steroids suppress immune system

Great question! Unfortunately, there are side effects to taking steroids – inhaled or oral. However, the risk of suppressing the immune system with inhaled corticosteroids is far less than with the use of systemic steroids.
For a person with asthma, inhaled steroids are an important part of treatment. They reduce the airway inflammation that is the hallmark of asthma. So, when prescribing inhaled steroids most doctors weigh carefully the benefits vs. the risks. Most likely you’re on the lowest possible dose for the severity of your asthma – enough to treat the inflammation and avoid exacerbations. One of the benefits of inhaled steroids is that they are being delivered directly to the area needed, which is one of the reasons a much lower dosing can be used with far less side effects. In fact, it takes about a year of inhaled steroids to equal a 5 day course of oral steroids prescribed during an exacerbation .

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