Gestational age 32 weeks or less, birth weight: 500 to 1500 g:
Initial dose: 10 mg/kg, followed by two doses of 5 mg/kg after 24 and 48 hours
Note: Use birth weight to calculate all doses. Hold second or third doses if urinary output is less than mL/kg/hour; may give when laboratory studies indicate renal function is back to normal. A second course of treatment, alternative pharmacologic therapy, or surgery may be needed if the ductus arteriosus fails to close or reopens following the initial course of therapy.
Jessie Szalay is a contributing writer for Live Science. She covers animals, health and other general science topics. Her work has appeared in the Jewish Daily Forward, National Geographic Traveler — Intelligent Travel, Killing the Buddha, Waccamaw Journal and elsewhere. Jessie is finishing her master's degree in nonfiction writing at George Mason University and holds a bachelor of arts degree from Kenyon College. She lives in Washington, ., and is working on a book about the sociological and psychological practice of othering.