Benzodiazepine therapy can give rise to physiologic and psychologic dependence based on the drug's dosage, duration of therapy and potency. 1 Thus, dependence will develop sooner (such as in one to two months) in a patient who is taking a high dosage of a high-potency agent such as alprazolam than in a patient who is receiving a relatively low dosage of a long-acting, low-potency agent such as chlordiazepoxide. As a result of physiologic dependence, withdrawal symptoms emerge with rapid dose reduction or abrupt discontinuation of the drug.
Salvia produces its effects by activating kappa opioid receptors (KOR) in the brain. The effects are altered perception of pain, mood, motor control, and consciousness. The KOR is a type of opioid receptor, but, differs from opioid receptors that are activated when using heroin or other opioids. The KOR may actually provide an addiction control mechanism and that is why salvia is not addictive. It also differs from other hallucinogens because it does not act on serotonin receptors and according to the National Institute on Drug Abuse ,” there is little evidence of salvia causing dependence or long-term psychiatric problems in humans.”