The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
I have severe asthma. I am 49 years old. I had a sinus surgery in 2004 and woke up wheezy – never had asthma before this! Eosinophils in my lungs for no reason. I have been on prednisone since 2004. Not real high doses, but many bursts that start at 100mg. My baseline for the last year has been 10mg a day. However, I started receiving Nucalla injections last fall and started a taper of my pred dosage not long after. As of June 2017, I am steroid free! Amen! However, I am feeling some serious side affects. I have extreme fatigue and joint pain. I felt fortunate that pred has not damaged me in some way for so long – until now. I am an avid runner and kept my weight down. When I couldn’t breath, I couldn’t run. So I would up the dose so I could keep fit. No bone damage or high blood sugar or high blood pressure. I credit this to maintaining a grueling workout schedule. After reading other posts, etc… I feel fortunate (knock on wood)……… I am working thru my adrenal gland issues with docs and I pray that I will recover soon from that as well. Thank you for your posts and let me know if I can help answer any questions of pred use. I have literally taken thousands of milligrams over the years…….