Steroid hormone receptor amplification

Sex hormone-binding globulin (SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of adenylyl cyclase and synthesis of the cAMP second messenger. [ 19 ] Hence the SHBG/SHBG-R complex appears to act as a transmembrane steroid receptor that is capable of transmitting signals to the interior of cells.

Steroid hormone receptor amplification

steroid hormone receptor amplification

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steroid hormone receptor amplificationsteroid hormone receptor amplificationsteroid hormone receptor amplificationsteroid hormone receptor amplificationsteroid hormone receptor amplification