Formulations of topical diclofenac, ibuprofen, ketoprofen, piroxicam, and indomethacin demonstrated significantly higher rates of clinical success (more participants with at least 50% pain relief) than matching topical placebo (moderate or high quality data ). Benzydamine did not. Three drug and formulation combinations had NNTs for clinical success below 4. For diclofenac, the Emulgel® formulation had the lowest NNT of (95% CI to ) in two studies using at least 50% pain intensity reduction as the outcome . Diclofenac plasters other than Flector® also had a low NNT of ( to ) based on good or excellent responses in some studies. Ketoprofen gel had an NNT of ( to ), from five studies in the 1980s, some with less well defined outcomes. Ibuprofen gel had an NNT of ( to ) from two studies with outcomes of marked improvement or complete remission. All other drug and formulation combinations had NNT values above 4, indicating lesser efficacy .
Dog food itself can have a positive impact on dogs that are suffering from arthritis. In a clinical study, dogs that were fed a diet specifically formulated for dogs with OA (osteoarthritis) such as Hill's Prescription Diet j/d , a food rich in Omega-3 fatty acids , showed improvement over dogs that had a similar arthritic condition, but that were fed an ordinary diet. The results of the study showed that "more dogs in the test group had a reduction in pain at the end of the 90-day trial." 82% of the dogs in the trial that received the new diet showed improvement.